Supplemental Data for:
Lim et al, Nature 433, pp. 769-773

 

Supplementary Discussion
Analysis of overlaps with computational predictions.
 
Supplementary Note
Sequences cloned into reporter vectors.
 
Supplementary Figure 1
Quantitative northern blot analysis of miR-1 and miR-124 expression.
 
Supplementary Figure 2
Tissue analysis for mutant microRNAs.
 
Supplementary Figure 3
Expected and observed seed match counts in different regions of miR-1 or miR-124 downregulated genes.
 
Supplementary Figure 4
p-values of enrichment for hexamers complementary to miR-124 in the 3' UTRs of the miR-124 downregulated genes.
 
Supplementary Figure 5
Motif and tissue analysis for miR-373.
 
Supplementary Table 1
Genes downregulated by miR-1 at a p-value < 0.001 at both 12 and 24 h.
 
Supplementary Table 2
Genes downregulated by miR-124 at a p-value < 0.001 at both 12 and 24 h.
 
Supplementary Table 3
Hexamers enriched in the 3' UTRs of the downregulated sets.
 
Supplementary Table 4
Genes downregulated by miR-373 at a p-value < 0.001 at both 12 and 24 h.
 
Supplementary Methods
This file contains MIAME (Minimum Information About a Microarray Experiment) methods data.